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The determination of quinidine in serum

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Published .
Written in English


Book details:

Edition Notes

Thesis (M.A.)--Boston University, 1949.

The Physical Object
Pagination59 pages
Number of Pages59
ID Numbers
Open LibraryOL26208048M
OCLC/WorldCa7905032

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Determination of quinidine in serum by spectrofluorometry, liquid chromatography and fluorescence scanning thin-layer chromatography. Journal of Chromatography B: Biomedical Sciences and Applications , , Cited by: Quinidine serum concentrations after an intravenous dose (diamonds with solid line) and three different oral tablets (doses normalized to provide mg of quinidine base systemically). After an intravenous dose, quinidine serum concentrations decline according to a two-compartment model which demonstrates a distribution phase that lasts for 20–30 minutes postinjection. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Quinidine in serum was measured at nm, after protein precipitation, with an alkyl phenyl reversed-phase chro-matographic column by peak-height determination (ex-ternal standards). Sensitivity was mg/liter, with linear response to at least 10 mg/liter serum. Quinidine serum concentrations after an intravenous dose (circles with solid line) and three different oral tablets (doses normalized to provide mg of quinidine base systemically). After an intravenous dose, quinidine serum concentrations decline according to a two-compartment model, which demonstrates a distribution phase that lasts for

The cardioactive drug quinidine has a narrow therapeutic index; consequently, determination of serum quinidine concentrations can be important. We describe a relatively rapid and specific assay. Quinidine should be dose adjusted in patients with congestive heart failure as normal dosing of the drug may lead to abnormally high serum concentrations. Pregnancy - Quinidine is an "FDA pregnancy risk category C" and is not safe during pregnancy, it can only be given when potential maternal benefit justifies the possible risk to the fetus. Quinidine is a secondary alcohol, the radicals in which are a 5-methyoxyquinoline ring and 3-vinylquinuclidine. Quinidine only differs from quinine in the configuration of the carbon atom of the carbinol group, and it can be made by isomerization of quinine () [4]. Quinidine is proposed to synthesize by different ways [5–7]. Quinidine - Quinidine is used in the treatment of acute and chronic supraventricular arrhythmias and ectopic rhythm disturbances. Quinidine clearance can be altered by changes in plasma proteins and in renal and/or hepatic dysfunction. Both quinidine and the related isomer quinine possess antimalarial schizonticide activity. Quinidine levels are monitored to assure adequate therapeutic levels.

Quinidine is the oldest primary antiarrhythmic drug in clinical practice. It is used to control atrial fibrillation and flutter and to suppress ventricular arrhythmias. Quinidine is usually administered orally and absorbed in the small intestine. About 80% of the quinidine in plasma is protein bound.   Edoxaban: QuiNIDine may increase the serum concentration of Edoxaban. Management: In patients treated for DVT/PE, reduce the edoxaban dose to 30 mg daily when combined with quinidine. No dose adjustment is recommended for patients treated for atrial fibrillation. Monitor for increased edoxaban toxicities (ie, bleeding) when combined. Calibration standards (prepared in newborn calf serum) were linear over the range 2–24 mg/L for quinine, and –8 mg/L for quinidine. • Analysis of internal QC solutions, prepared in pooled human serum (5 and 15 mg/L quinine, 2 and 5 mg/L for quinidine) gave: intra-assay CV. In a single-blind cross-over study, 6 healthy volunteers took three different formulations, each containing g of quinidine base, every 12 h for 96 h. A mean steady state serum level of mg/l of quinidine base was produced by bisulphate tablets that dissolved rapidly. Long-acting Quinidine Durules® (sustained-release quinidine bisulphate) produced a mean steady state serum level that.